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Switching on Your Longevity Gene

     My patients and regular readers know I’m big on supplements. I’ve learned that many supplements have the power to ward off health problems before they happen.

     But every once in a while, a supplement comes along that exceeds even my wildest expectations. CoQ10 was one of them. Now I’d like to add another supplement to that list. And it’s one you may know well.

A Truly Multi-purpose Supplement

     You’re probably familiar with resveratrol. It’s called a polyphenol, and it occurs naturally in plants. It’s found in the skin of grapes, peanuts and other plants. And it’s been linked to an impressive list of health benefits:

  • Skin – Resveratrol a protects skin from damaging ultraviolet B light.1
     
  • Brain – Italian scientists discovered resveratrol may protect your brain from the negative effects of aging.2
     
  • Cartilage – Animal studies show that resveratrol may help repair damaged cartilage – even in the spinal column.3
     
  • Lungs – In a Korean study, resveratrol significantly reduced breathing problems. In fact, researchers said it worked as well as a common medicine.4
     
  • Muscles – Resveratrol protects skeletal muscles from oxidative stress. It even helps individual muscle cells resist “cell death.”5

     The list goes on and on. For example, such well-known benefits as protecting your heart and acting as a powerful antioxidant.6

     These are all good reasons to take resveratrol. But it’s another area of resveratrol research that has me most excited. One you may not be familiar with.

Unexpected Health Benefits

     As you may know, restricting caloric intake can slow the negative effects of aging. That’s because restricting calories activates a stress-related gene called SirT1.

     Here’s what happens when SirT1 is activated:

  • Visceral (midsection) fat levels drop
  • Insulin resistance goes down
  • LDL (“bad”) cholesterol decreases
  • Inflammation calms
  • Several other healthy changes take place, as well.7

     Its no wonder that SirT1 is often called “the Longevity Gene.” It reverses most of the common risk factors for heart and blood sugar problems.

     So what does this have to do with resveratrol?

     Just this: Several studies have now shown that resveratrol mimics caloric restriction… and activates theSirT1 gene.8 In other words, resveratrol gives you serious protection from some of the worst health problems linked to aging.

     But that’s not all.

14 Times the Antioxidant Protection

     A recent study from Canada’s Brock University had amazing results. Researchers found that resveratrol stimulated a 14-fold increase in the activity of a protein called MnSOD (mangenese superoxide dismutase).9

     MnSOD is a key antioxidant in your cell’s mitochondria. Mitochondria are your body’s “cellular engines” – producing the energy used in every cell. And MnSOD keeps them humming along smoothly.

     So, not only is resveratrol an effective antioxidant itself, it revs up a second powerful antioxidant, too.

Resveratrol – With a Bonus

     You can probably see why resveratrol is one of my favorite all-round supplements, and I’m very proud of the Resveratrol product my forward thinking associates at Best Life Herbals have created. That’s because they’ve added a perfect bonus to their resveratrol formula: pomegranate.

     Pomegranate adds extra protection as a powerful antioxidant. In fact, when Cornell University compared the antioxidant power of 25 common fruits, pomegranates came out on top.10

     Plus, pomegranate has been proven to lower total cholesterol and LDL cholesterol without affecting the levels of HDL (“good”) cholesterol in your blood. Together, resveratrol and pomegranate can give your health a powerful boost.

     There’s still a lot of exciting research going on into resveratrol. I’ll be sure to keep you informed as more news comes out.
 

Yours In Good Health,

Best Life Herbals Wellness Team
Best Life Herbals

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1 Regan-Shaw S, et al. Resveratrol imparts photoprotection of normal cells and enhances the efficacy of radiation therapy in cancer cells. Photochem Photobiol. 2008 Mar-Apr;84(2):415-21. Epub 2008 Jan 23.
2 Rossi L, et al. Benefits from dietary polyphenols for brain aging and Alzheimer’s disease. Neurochem Res. 2008 Dec;33(12):2390-400. Epub 2008 Apr 16.
3 Li X, et al. The action of resveratrol, a phytoestrogen found in grapes, on the intervertebral disc. Spine (Phila Pa 1976). 2008 Nov 15;33(24):2586-95.
4 Lee M, et al. Anti-inflammatory and anti-asthmatic effects of resveratrol, a polyphenolic stilbene, in a mouse model of allergic asthma. Int Immunopharmacol. 2009 Apr;9(4):418-24. Epub 2009 Feb 8.
5 Dirks Naylor AJ. Cellular effects of resveratrol in skeletal muscle. Life Sci. 2009 May 8;84(19-20):637-40. Epub 2009 Feb 21.
6 Marques FZ, et al. Resveratrol: cellular actions of a potent natural chemical that confers a diversity of health benefits. Int J Biochem Cell Biol. 2009 Nov;41(11):2125-8. Epub 2009 Jun 13.
7 Daniel Sedding and Judith Haendeler. Do We Age on Sirt1 Expression? Circulation Research. 2007;100:1396-1398.
8 Lekli I, et al. Longevity nutrients resveratrol, wines and grapes. Genes Nutr. 2009 Sep 4. [Epub ahead of print]
9 Robb EL, et al. Molecular mechanisms of oxidative stress resistance induced by resveratrol: Specific and progressive induction of MnSOD. Biochem Biophys Res Commun. 2008 Mar 7;367(2):406-12. Epub 2007 Dec 31.
10 Wolfe KL, et al. Cellular antioxidant activity of common fruits. J Agric Food Chem. 2008 Sep 24;56(18):8418-26. Epub 2008 Aug 30.

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